Another nit to pick: long lines in docstrings.  There are several lines about 75-78 characters long in several different docstrings, which look absolutely terrible when you try "import os;help(os)" on an 80-character-wide terminal due to an 8 character indent.  Blame can be spread pretty far and wide on this, but I wonder if Clinic should enforce a 72 character limit on docstring lines to try to mitigate this?

Other than that (and the fix to utime mentioned earlier), I don't see anything obviously wrong with the patch, though I admit to not having read through the whole thing (it's huge!).