> If we make this work, aren't people going to expect [[1,2], [3,4]][0,1] to work?

Or even [[1,2], [3,4]][*(0,1)] :-)

But seriously, I don't know. memorview is a pretty specialized object, its semantics have more to do with Numpy (which has been a major inspiration and use case for the buffer protocol's design) than standard Python containers. I wouldn't expect a list of lists to support tuple indexing.