"Trying to run the python interpreter in a chroot fails if /dev/urandom is not present."

The workaround is simple: fix your chroot to correctly expose /dev/urandom in the chroot. It's a common and known issue, no?

Since the issue is almost dead since 2 years and I don't know if arc4random() is suitable for os.urandom(), I close the issue. If you want to reopen it, please come back with more information on arc4random() security ;-)